Specific Activity of C-Labelled Radiotracers: A Big Challenge for PET Chemists
نویسندگان
چکیده
Non-invasive in vivo molecular imaging using radionuclides is based on the Radiotracer Principle of G. von Hevesy and the magic bullet concept by Ehrlich (1990). Both principles require administration of a radioactive tracer (a molecule labelled with a radioactive isotope which when injected into a living object can be traced by external radiation detection devices) and require that the quantity is in sub-pharmacological amounts, i.e. that minimal mass is injected, which in radiopharmaceutical terms means high specific activity.
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